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Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice
DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation as a major controller of repair pathway choice. Neddylation inhibition cha...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333419/ https://ncbi.nlm.nih.gov/pubmed/25567988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1384 |
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