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Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation as a major controller of repair pathway choice. Neddylation inhibition cha...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Jimeno, Sonia, Fernández-Ávila, María Jesús, Cruz-García, Andrés, Cepeda-García, Cristina, Gómez-Cabello, Daniel, Huertas, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333419/
https://ncbi.nlm.nih.gov/pubmed/25567988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1384
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