CtIP Links DNA Double-strand Break Sensing to Resection

In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recombination (HR). However, the biochem...

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Autors principals: You, Zhongsheng, Shi, Linda Z., Zhu, Quan, Wu, Peng, Zhang, You-Wei, Basilio, Andrew, Tonnu, Nina, Verma, Inder M., Berns, Michael W., Hunter, Tony
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807415/
https://ncbi.nlm.nih.gov/pubmed/20064462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.002
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