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CtIP Links DNA Double-strand Break Sensing to Resection
In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recombination (HR). However, the biochem...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2807415/ https://ncbi.nlm.nih.gov/pubmed/20064462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.002 |
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