CtIP Protein Dimerization Is Critical for Its Recruitment to Chromosomal DNA Double-stranded Breaks

CtIP (CtBP-interacting protein) associates with BRCA1 and the Mre11-Rad50-Nbs1 (MRN) complex and plays an essential role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair. It has been described that CtIP forms dimers in mammalian cells, but the biological significance...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Hailong, Shao, Zhengping, Shi, Linda Z., Hwang, Patty Yi-Hwa, Truong, Lan N., Berns, Michael W., Chen, David J., Wu, Xiaohua
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375568/
https://ncbi.nlm.nih.gov/pubmed/22544744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355354
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