Catalytic and non-catalytic roles of the CtIP endonuclease in double-strand break end resection

The CtIP protein is known to function in 5′ strand resection during homologous recombination similar to the budding yeast Sae2 protein, although its role in this process is unclear. Here we characterize recombinant human CtIP and find that it exhibits 5′ flap endonuclease activity on branched DNA st...

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Bibliografiske detaljer
Main Authors: Makharashvili, Nodar, Tubbs, Anthony T., Yang, Soo-Hyun, Wang, Hailong, Barton, Olivia, Zhou, Yi, Deshpande, Rajashree A., Lee, Ji-Hoon, Lobrich, Markus, Sleckman, Barry P., Wu, Xiaohua, Paull, Tanya T.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079050/
https://ncbi.nlm.nih.gov/pubmed/24837676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.011
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