The Mre11/Rad50/Nbs1 Complex: recent insights into catalytic activities and ATP-driven conformational changes

Por Paull, Tanya T., Deshpande, Rajashree A.
Publicado no Exp Cell Res (2014)

Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4

Por Deshpande, Rajashree A., Wilson, Thomas E.
Publicado em 2007

Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites

Por Deshpande, Rajashree A., Lee, Ji-Hoon, Paull, Tanya T.
Publicado no Nucleic Acids Res (2017)

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

Por Lee, Ji-Hoon, Mand, Michael R., Deshpande, Rajashree A., Kinoshita, Eri, Yang, Soo-Hyun, Wyman, Claire, Paull, Tanya T.
Publicado em 2013

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast

Por Arora, Sucheta, Deshpande, Rajashree A., Budd, Martin, Campbell, Judy, Revere, America, Zhang, Xiaoming, Schmidt, Kristina H., Paull, Tanya T.
Publicado no Mol Cell Biol (2017)

Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair

Por Myler, Logan R., Gallardo, Ignacio F., Soniat, Michael M., Deshpande, Rajashree A., Gonzalez, Xenia B., Kim, Yoori, Paull, Tanya T., Finkelstein, Ilya J.
Publicado no Mol Cell (2017)

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

Por Deshpande, Rajashree A, Williams, Gareth J, Limbo, Oliver, Williams, R Scott, Kuhnlein, Jeff, Lee, Ji-Hoon, Classen, Scott, Guenther, Grant, Russell, Paul, Tainer, John A, Paull, Tanya T
Publicado em 2014

ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

Por Deshpande, Rajashree A, Williams, Gareth J, Limbo, Oliver, Williams, R Scott, Kuhnlein, Jeff, Lee, Ji‐Hoon, Classen, Scott, Guenther, Grant, Russell, Paul, Tainer, John A, Paull, Tanya T
Publicado no EMBO J (2016)

Catalytic and non-catalytic roles of the CtIP endonuclease in double-strand break end resection

Por Makharashvili, Nodar, Tubbs, Anthony T., Yang, Soo-Hyun, Wang, Hailong, Barton, Olivia, Zhou, Yi, Deshpande, Rajashree A., Lee, Ji-Hoon, Lobrich, Markus, Sleckman, Barry P., Wu, Xiaohua, Paull, Tanya T.
Publicado em 2014