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Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair
DNA double-strand break (DSB) repair is essential for maintaining our genomes. Mre11-Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the interplay between these complexes at a DSB remains unclear. Here, we use high-throughput single-molecule microscopy to show that MRN s...
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Publicado no: | Mol Cell |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5609712/ https://ncbi.nlm.nih.gov/pubmed/28867292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.08.002 |
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