Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

The Ataxia Telangiectasia-Mutated (ATM) protein kinase is recruited to sites of double-strand DNA breaks by the Mre11/Rad50/Nbs1 (MRN) complex, which also facilitates ATM monomerization and activation. MRN exists in at least two distinct conformational states, dependent on ATP binding and hydrolysis...

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Главные авторы: Lee, Ji-Hoon, Mand, Michael R., Deshpande, Rajashree A., Kinoshita, Eri, Yang, Soo-Hyun, Wyman, Claire, Paull, Tanya T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
DNA and Chromosomes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642328/
https://ncbi.nlm.nih.gov/pubmed/23525106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.460378
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