Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex

The Mre11-Rad50-Nbs1 (MRN) complex coordinates the repair of DNA double-strand breaks, replication fork restart, meiosis, class-switch recombination, and telomere maintenance. As such, MRN is an essential molecular machine that has homologs in all organisms of life, from bacteriophage to humans. In...

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Udgivet i:Methods Mol Biol
Main Authors: Myler, Logan R., Soniat, Michael M., Zhang, Xiaoming, Deshpande, Rajashree A., Paull, Tanya T., Finkelstein, Ilya J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667175/
https://ncbi.nlm.nih.gov/pubmed/31147924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-9520-2_20
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