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Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites
The Mre11–Rad50–Nbs1(Xrs2) (MRN/X) complex is critical for the repair and signaling of DNA double strand breaks. The catalytic core of MRN/X comprised of the Mre11 nuclease and Rad50 adenosine triphosphatase (ATPase) active sites dimerizes through association between the Rad50 ATPase catalytic domai...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5435944/ https://ncbi.nlm.nih.gov/pubmed/28369545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx173 |
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