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Activation of Tel1(ATM) kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends

In Saccharomyces cerevisiae, Tel1 protein kinase, the ortholog of human ataxia telangiectasia–mutated (ATM), is activated in response to DNA double-strand breaks. Biochemical studies with human ATM and genetic studies in yeast suggest that recruitment and activation of Tel1(ATM) depends on the heter...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Hailemariam, Sarem, Kumar, Sandeep, Burgers, Peter M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664182/
https://ncbi.nlm.nih.gov/pubmed/31073030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008410
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