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Activation of Tel1(ATM) kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends
In Saccharomyces cerevisiae, Tel1 protein kinase, the ortholog of human ataxia telangiectasia–mutated (ATM), is activated in response to DNA double-strand breaks. Biochemical studies with human ATM and genetic studies in yeast suggest that recruitment and activation of Tel1(ATM) depends on the heter...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6664182/ https://ncbi.nlm.nih.gov/pubmed/31073030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008410 |
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