Načítá se...

The telomere-binding protein Rif2 and ATP-bound Rad50 have opposing roles in the activation of yeast Tel1(ATM) kinase

Saccharomyces cerevisiae Tel1 is the ortholog of human ATM kinase and initiates a cell cycle checkpoint in response to dsDNA breaks (DSBs). Tel1(ATM) kinase is activated synergistically by naked dsDNA and the Mre11-Rad50-Xrs2(NBS1) complex (MRX). A multisubunit protein complex, which is related to h...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Hailemariam, Sarem, De Bona, Paolo, Galletto, Roberto, Hohl, Marcel, Petrini, John H., Burgers, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901328/
https://ncbi.nlm.nih.gov/pubmed/31640985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011077
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!