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The telomere-binding protein Rif2 and ATP-bound Rad50 have opposing roles in the activation of yeast Tel1(ATM) kinase
Saccharomyces cerevisiae Tel1 is the ortholog of human ATM kinase and initiates a cell cycle checkpoint in response to dsDNA breaks (DSBs). Tel1(ATM) kinase is activated synergistically by naked dsDNA and the Mre11-Rad50-Xrs2(NBS1) complex (MRX). A multisubunit protein complex, which is related to h...
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| Yayımlandı: | J Biol Chem |
|---|---|
| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6901328/ https://ncbi.nlm.nih.gov/pubmed/31640985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011077 |
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