The Dimeric Architecture of Checkpoint Kinases Mec1(ATR) and Tel1(ATM) Reveal a Common Structural Organization

The phosphatidylinositol 3-kinase-related protein kinases are key regulators controlling a wide range of cellular events. The yeast Tel1 and Mec1·Ddc2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling, and repair. Here, we present the first structural...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sawicka, Marta, Wanrooij, Paulina H., Darbari, Vidya C., Tannous, Elias, Hailemariam, Sarem, Bose, Daniel, Makarova, Alena V., Burgers, Peter M., Zhang, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919432/
https://ncbi.nlm.nih.gov/pubmed/27129217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708263
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