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The Dimeric Architecture of Checkpoint Kinases Mec1(ATR) and Tel1(ATM) Reveal a Common Structural Organization
The phosphatidylinositol 3-kinase-related protein kinases are key regulators controlling a wide range of cellular events. The yeast Tel1 and Mec1·Ddc2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling, and repair. Here, we present the first structural...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4919432/ https://ncbi.nlm.nih.gov/pubmed/27129217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708263 |
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