Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends

Tel1/ATM and Mec1/ATR checkpoint kinases are activated by DNA double-strand breaks (DSBs). Mec1/ATR recruitment to DSBs requires the formation of RPA-coated single-stranded DNA (ssDNA), which arises from 5′–3′ nucleolytic degradation (resection) of DNA ends. Here, we show that Saccharomyces cerevisi...

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Main Authors: Clerici, Michela, Trovesi, Camilla, Galbiati, Alessandro, Lucchini, Giovanna, Longhese, Maria Pia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Publishing Ltd 2014
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989615/
https://ncbi.nlm.nih.gov/pubmed/24357557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201386041
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