DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

The repair of DNA double-strand breaks occurs through nonhomologous end joining or homologous recombination in vertebrate cells—a choice that is thought to be decided by a competition between DNA-dependent protein kinase (DNA-PK) and the Mre11/Rad50/Nbs1 (MRN) complex but is not well understood. Usi...

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Udgivet i:Sci Adv
Main Authors: Deshpande, Rajashree A., Myler, Logan R., Soniat, Michael M., Makharashvili, Nodar, Lee, Linda, Lees-Miller, Susan P., Finkelstein, Ilya J., Paull, Tanya T.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949041/
https://ncbi.nlm.nih.gov/pubmed/31934630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay0922
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