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MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

Repair of DNA double-strand breaks (DSBs) with complex ends poses a special challenge, as additional processing is required before DNA ligation. For example, protein–DNA adducts must be removed to allow repair by either nonhomologous end joining or homology-directed repair. Here, we investigated the...

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Pubblicato in:J Cell Biol
Autori principali: Aparicio, Tomas, Baer, Richard, Gottesman, Max, Gautier, Jean
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754713/
https://ncbi.nlm.nih.gov/pubmed/26880199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504005
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