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Activation of DSB processing requires phosphorylation of CtIP by ATR
DNA double-strand breaks (DSBs) activate a DNA damage response (DDR) that coordinates checkpoint pathways with DNA repair. ATM and ATR kinases are activated sequentially. Homology-directed repair (HDR) is initiated by resection of DSBs to generate 3′ ssDNA overhangs. How resection and HDR are activa...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582837/ https://ncbi.nlm.nih.gov/pubmed/23273981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.020 |
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