Activation of DSB processing requires phosphorylation of CtIP by ATR

DNA double-strand breaks (DSBs) activate a DNA damage response (DDR) that coordinates checkpoint pathways with DNA repair. ATM and ATR kinases are activated sequentially. Homology-directed repair (HDR) is initiated by resection of DSBs to generate 3′ ssDNA overhangs. How resection and HDR are activa...

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Détails bibliographiques
Auteurs principaux: Peterson, Shaun Eric, Li, YinYin, Wu-Baer, Foon, Chait, Brian, Baer, Richard, Yan, Hong, Gottesman, Max, Gautier, Jean
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582837/
https://ncbi.nlm.nih.gov/pubmed/23273981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.020
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