Activation of DSB processing requires phosphorylation of CtIP by ATR

DNA double-strand breaks (DSBs) activate a DNA damage response (DDR) that coordinates checkpoint pathways with DNA repair. ATM and ATR kinases are activated sequentially. Homology-directed repair (HDR) is initiated by resection of DSBs to generate 3′ ssDNA overhangs. How resection and HDR are activa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Peterson, Shaun Eric, Li, YinYin, Wu-Baer, Foon, Chait, Brian, Baer, Richard, Yan, Hong, Gottesman, Max, Gautier, Jean
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582837/
https://ncbi.nlm.nih.gov/pubmed/23273981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.020
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