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Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair
DNA double-strand break (DSB) resection, which results in RPA-bound single-stranded DNA (ssDNA), is activated in S phase by Cdk2. RPA-ssDNA activates the ATR-dependent checkpoint and homology-directed repair (HDR) via Rad51-dependent mechanisms. On the other hand, the fate of DSBs sustained during v...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3171114/ https://ncbi.nlm.nih.gov/pubmed/21893598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201103103 |
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