Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair

DNA double-strand break (DSB) resection, which results in RPA-bound single-stranded DNA (ssDNA), is activated in S phase by Cdk2. RPA-ssDNA activates the ATR-dependent checkpoint and homology-directed repair (HDR) via Rad51-dependent mechanisms. On the other hand, the fate of DSBs sustained during v...

Full description

Saved in:
Bibliographic Details
Main Authors: Peterson, Shaun E., Li, Yinyin, Chait, Brian T., Gottesman, Max E., Baer, Richard, Gautier, Jean
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2011
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171114/
https://ncbi.nlm.nih.gov/pubmed/21893598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201103103
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items