BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains specifically recognize phospho-serine motifs. Here, we demonstrate that BRCA1 Ring domain catalyzes CtIP u...

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Bibliografske podrobnosti
Main Authors: Yu, Xiaochun, Fu, Shuang, Lai, Maoyi, Baer, Richard, Chen, Junjie
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2006
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1522068/
https://ncbi.nlm.nih.gov/pubmed/16818604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1431006
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