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FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks
FANCJ helicase mutations are known to cause hereditary breast and ovarian cancers as well as bone marrow failure syndrome Fanconi anemia. FANCJ plays an important role in the repair of DNA inter-strand crosslinks and DNA double-strand breaks (DSBs) by homologous recombination (HR). Nonetheless, the...
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| Veröffentlicht in: | PLoS Genet |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7162537/ https://ncbi.nlm.nih.gov/pubmed/32251466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008701 |
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