Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

Topoisomerase inhibitors such as camptothecin and etoposide are used as anti-cancer drugs and induce double-strand breaks (DSBs) in genomic DNA in cycling cells. These DSBs are often covalently bound with polypeptides at the 3′ and 5′ ends. Such modifications must be eliminated before DSB repair can...

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Main Authors: Nakamura, Kyoko, Kogame, Toshiaki, Oshiumi, Hiroyuki, Shinohara, Akira, Sumitomo, Yoshiki, Agama, Keli, Pommier, Yves, Tsutsui, Kimiko M., Tsutsui, Ken, Hartsuiker, Edgar, Ogi, Tomoo, Takeda, Shunichi, Taniguchi, Yoshihito
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809774/
https://ncbi.nlm.nih.gov/pubmed/20107609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000828
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