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BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

Homologous recombination plays a key role in the repair of double-strand breaks (DSBs), and thereby significantly contributes to cellular tolerance to radiotherapy and some chemotherapy. DSB repair by homologous recombination is initiated by 5’ to 3’ strand resection (DSB resection), with nucleases...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Hoa, Nguyen Ngoc, Kobayashi, Junya, Omura, Masato, Hirakawa, Mayumi, Yang, Soo-Hyun, Komatsu, Kenshi, Paull, Tanya T., Takeda, Shunichi, Sasanuma, Hiroyuki
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409214/
https://ncbi.nlm.nih.gov/pubmed/25909997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124495
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