BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

The accurate maintenance of genomic integrity is essential for tissue homeostasis. Deregulation of this process leads to cancer and aging. BRCA1 is a critical mediator of this process. Here, we performed conditional deletion of Brca1 during epidermal development and found that BRCA1 is specifically...

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Detalhes bibliográficos
Main Authors: Sotiropoulou, Panagiota A., Karambelas, Andrea E., Debaugnies, Maud, Candi, Aurelie, Bouwman, Peter, Moers, Virginie, Revenco, Tatiana, Rocha, Ana Sofia, Sekiguchi, Kiyotoshi, Jonkers, Jos, Blanpain, Cedric
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553282/
https://ncbi.nlm.nih.gov/pubmed/23271346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.206573.112
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