BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

The accurate maintenance of genomic integrity is essential for tissue homeostasis. Deregulation of this process leads to cancer and aging. BRCA1 is a critical mediator of this process. Here, we performed conditional deletion of Brca1 during epidermal development and found that BRCA1 is specifically...

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Hauptverfasser: Sotiropoulou, Panagiota A., Karambelas, Andrea E., Debaugnies, Maud, Candi, Aurelie, Bouwman, Peter, Moers, Virginie, Revenco, Tatiana, Rocha, Ana Sofia, Sekiguchi, Kiyotoshi, Jonkers, Jos, Blanpain, Cedric
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553282/
https://ncbi.nlm.nih.gov/pubmed/23271346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.206573.112
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