Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX generates lysophosphatidic acid (LPA), a lipid mitogen and motility factor that acts on several G protein-coupled receptors. Here we r...

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Detalhes bibliográficos
Main Authors: van Meeteren, Laurens A., Ruurs, Paula, Stortelers, Catelijne, Bouwman, Peter, van Rooijen, Marga A., Pradère, Jean Philippe, Pettit, Trevor R., Wakelam, Michael J. O., Saulnier-Blache, Jean Sébastien, Mummery, Christine L., Moolenaar, Wouter H., Jonkers, Jos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489177/
https://ncbi.nlm.nih.gov/pubmed/16782887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02419-05
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