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Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D

FTY720 is an immunomodulator that is phosphorylated in vivo and inhibits lymphocyte mobilization by targeting sphingosine 1-phospate receptors. At doses higher than required for immunomodulation, FTY720 inhibits tumor progression through an unknown mechanism. Here we show that FTY720-phosphate is a...

詳細記述

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書誌詳細
主要な著者: van Meeteren, Laurens A., Brinkmann, Volker, Saulnier-Blache, Jean Sébastien, Lynch, Kevin R., Moolenaar, Wouter H.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943588/
https://ncbi.nlm.nih.gov/pubmed/18378389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.02.052
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