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(S)-FTY720-Vinylphosphonate, an Analogue of the Immunosuppressive Agent FTY720, Is a Pan-antagonist of Sphingosine 1-Phosphate GPCR Signaling and Inhibits Autotaxin Activity

FTY720 (Fingolimod™), a synthetic analogue of sphingosine 1-phosphate (S1P), activates four of the five EDG-family S1P receptors and is in a phase-III clinical study for the treatment of multiple sclerosis. (S)-FTY720-phosphate (FTY720-P) causes S1P(1) receptor internalization and targeting to the p...

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Main Authors:	Valentine, William J., Kiss, Gyöngyi N., Liu, Jianxiong, Shuyu, E, Gotoh, Mari, Murokami-Murofushi, Kimiko, Pham, Truc Chi, Baker, Daniel L., Parrill, Abby L., Lu, Xuequan, Sun, Chaode, Bittman, Robert, Pyne, Nigel J., Tigyi, Gabor
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2010
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3446790/ https://ncbi.nlm.nih.gov/pubmed/20566326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.05.023
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(S)-FTY720-Vinylphosphonate, an Analogue of the Immunosuppressive Agent FTY720, Is a Pan-antagonist of Sphingosine 1-Phosphate GPCR Signaling and Inhibits Autotaxin Activity

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