Загрузка...
(S)-FTY720-Vinylphosphonate, an Analogue of the Immunosuppressive Agent FTY720, Is a Pan-antagonist of Sphingosine 1-Phosphate GPCR Signaling and Inhibits Autotaxin Activity
FTY720 (Fingolimod™), a synthetic analogue of sphingosine 1-phosphate (S1P), activates four of the five EDG-family S1P receptors and is in a phase-III clinical study for the treatment of multiple sclerosis. (S)-FTY720-phosphate (FTY720-P) causes S1P(1) receptor internalization and targeting to the p...
Сохранить в:
| Главные авторы: | , , , , , , , , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3446790/ https://ncbi.nlm.nih.gov/pubmed/20566326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.05.023 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|