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Chiral Vinylphosphonate and Phosphonate Analogues of the Immunosuppressive Agent FTY720
[Image: see text] The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)-vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent anti-apoptotic effect in intestinal epithelial cells, suggesting that it exe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747615/ https://ncbi.nlm.nih.gov/pubmed/19296586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo900023u |
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