Chiral Vinylphosphonate and Phosphonate Analogues of the Immunosuppressive Agent FTY720

[Image: see text] The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)-vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent anti-apoptotic effect in intestinal epithelial cells, suggesting that it exe...

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Hlavní autoři: Lu, Xuequan, Sun, Chaode, Valentine, William J., E, Shuyu, Liu, Jianxiong, Tigyi, Gabor, Bittman, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747615/
https://ncbi.nlm.nih.gov/pubmed/19296586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo900023u
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