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FTY720 (S)-Phosphonate Preserves S1PR1 Expression and Exhibits Superior Barrier Protection to FTY720 in Acute Lung Injury
OBJECTIVE: Effective therapies are needed to reverse the increased vascular permeability that characterizes acute inflammatory diseases such as acute lung injury (ALI). FTY720 is a pharmaceutical analog of the potent barrier-enhancing phospholipid, sphingosine 1-phosphate (S1P). Because both FTY720...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144721/ https://ncbi.nlm.nih.gov/pubmed/24335440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000097 |
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