FTY720 (S)-Phosphonate Preserves S1PR1 Expression and Exhibits Superior Barrier Protection to FTY720 in Acute Lung Injury

OBJECTIVE: Effective therapies are needed to reverse the increased vascular permeability that characterizes acute inflammatory diseases such as acute lung injury (ALI). FTY720 is a pharmaceutical analog of the potent barrier-enhancing phospholipid, sphingosine 1-phosphate (S1P). Because both FTY720...

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Autori principali: Wang, Lichun, Sammani, Saad, Moreno-Vinasco, Liliana, Letsiou, Eleftheria, Wang, Ting, Camp, Sara M., Bittman, Robert, Garcia, Joe G.N., Dudek, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144721/
https://ncbi.nlm.nih.gov/pubmed/24335440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000097
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