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JUNCTIONAL COMPLEX AND FOCAL ADHESION REARRANGEMENT MEDIATES PULMONARY ENDOTHELIAL BARRIER ENHANCEMENT BY FTY720 S-PHOSPHONATE

RATIONALE: Modulation of pulmonary vascular barrier function is an important clinical goal given the devastating effects of vascular leak in acute lung injury (ALI). We previously demonstrated that FTY720 S-phosphonate (Tys), an analog of sphingosine 1-phosphate (S1P) and FTY720, has more potent pul...

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Detalhes bibliográficos
Publicado no:Microvasc Res
Main Authors: Wang, Lichun, Bittman, Robert, Garcia, Joe G.N., Dudek, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032626/
https://ncbi.nlm.nih.gov/pubmed/25862132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mvr.2015.03.007
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