Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is enhanced in obese/insulin-resistant individuals. Here, we analyzed the specific contribution of adipose-ATX to fat expansion associ...

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Main Authors: Dusaulcy, Rodolphe, Rancoule, Chloé, Grès, Sandra, Wanecq, Estelle, Colom, André, Guigné, Charlotte, van Meeteren, Laurens A., Moolenaar, Wouter H., Valet, Philippe, Saulnier-Blache, Jean Sébastien
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090245/
https://ncbi.nlm.nih.gov/pubmed/21421848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014985
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