PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

The PI3K pathway integrates extracellular stimuli to phosphorylate effectors such as AKT and serum-and-glucocorticoid-regulated kinase (SGK1). We have previously reported that the PI3K pathway regulates estrogen receptor (ER)-dependent transcription in breast cancer through the phosphorylation of th...

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Publicado no:Cell Rep
Main Authors: Toska, Eneda, Castel, Pau, Chhangawala, Sagar, Arruabarrena-Aristorena, Amaia, Chan, Carmen, Hristidis, Vasilis C., Cocco, Emiliano, Sallaku, Mirna, Xu, Guotai, Park, Jane, Minuesa, Gerard, Shifman, Sophie G., Socci, Nicholas D., Koche, Richard, Leslie, Christina S., Scaltriti, Maurizio, Baselga, José
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503687/
https://ncbi.nlm.nih.gov/pubmed/30943409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.111
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