FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer

Mutations in the pioneer transcription factor FOXA1 are a hallmark of estrogen receptor-positive (ER(+)) breast cancers. Examining FOXA1 in ~5,000 breast cancer patients identifies several hotspot mutations in the Wing2 region and a breast cancer-specific mutation SY242CS, located in the third β str...

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Publicado no:Cancer Cell
Main Authors: Arruabarrena-Aristorena, Amaia, Maag, Jesper L.V., Kittane, Srushti, Cai, Yanyan, Karthaus, Wouter R., Ladewig, Erik, Park, Jane, Kannan, Srinivasaraghavan, Ferrando, Lorenzo, Cocco, Emiliano, Ho, Sik Y., Tan, Daisylyn S., Sallaku, Mirna, Wu, Fan, Acevedo, Barbara, Selenica, Pier, Ross, Dara S., Witkin, Matthew, Sawyers, Charles L., Reis-Filho, Jorge S., Verma, Chandra S., Jauch, Ralf, Koche, Richard, Baselga, José, Razavi, Pedram, Toska, Eneda, Scaltriti, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311901/
https://ncbi.nlm.nih.gov/pubmed/32888433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.08.003
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