PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in breast cancer. PI3Kα inhibitors are in clinical development and despite promising early clinical activity, intrinsic resistance is frequent among patients. We have previously reported that residual downstream mTO...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Cell
Hauptverfasser: Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982440/
https://ncbi.nlm.nih.gov/pubmed/27451907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.06.004
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge