PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in breast cancer. PI3Kα inhibitors are in clinical development and despite promising early clinical activity, intrinsic resistance is frequent among patients. We have previously reported that residual downstream mTO...

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Publicado en:Cancer Cell
Main Authors: Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982440/
https://ncbi.nlm.nih.gov/pubmed/27451907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.06.004
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