PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in breast cancer. PI3Kα inhibitors are in clinical development and despite promising early clinical activity, intrinsic resistance is frequent among patients. We have previously reported that residual downstream mTO...

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Vydáno v:Cancer Cell
Hlavní autoři: Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982440/
https://ncbi.nlm.nih.gov/pubmed/27451907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.06.004
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