Accelerating discovery of functional mutant alleles in cancer

Most mutations in cancer are rare, which complicates the identification of therapeutically significant mutations and thus limits the clinical impact of genomic profiling in cancer patients. Here, we analyzed 24,592 cancers including 10,336 prospectively sequenced patients with advanced disease to id...

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Publicat a:Cancer Discov
Autors principals: Chang, Matthew T., Bhattarai, Tripti Shrestha, Schram, Alison M., Bielski, Craig M., Donoghue, Mark T.A., Jonsson, Philip, Chakravarty, Debyani, Phillips, Sarah, Kandoth, Cyriac, Penson, Alexander, Gorelick, Alexander, Shamu, Tambudzai, Patel, Swati, Harris, Christopher, Gao, JianJiong, Sumer, Selcuk Onur, Kundra, Ritika, Razavi, Pedram, Li, Bob T., Reales, Dalicia N., Socci, Nicholas D., Jayakumaran, Gowtham, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria E, Chandarlapaty, Sarat, Ladanyi, Marc, Schultz, Nikolaus, Baselga, Jose, Berger, Michael F., Rosen, Neal, Solit, David B., Hyman, David M., Taylor, Barry S.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809279/
https://ncbi.nlm.nih.gov/pubmed/29247016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0321
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