Genome doubling shapes the evolution and prognosis of advanced cancers

Ploidy abnormalities are a hallmark of human cancers, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied by tumor lineage and molecular...

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Pubblicato in:Nat Genet
Autori principali: Bielski, Craig M., Zehir, Ahmet, Penson, Alexander V., Donoghue, Mark T.A., Chatila, Walid, Armenia, Joshua, Chang, Matthew T., Schram, Alison M., Jonsson, Philip, Bandlamudi, Chaitanya, Razavi, Pedram, Iyer, Gopa, Robson, Mark E., Stadler, Zsofia K., Schultz, Nikolaus, Baselga, Jose, Solit, David B., Hyman, David M., Berger, Michael F., Taylor, Barry S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072608/
https://ncbi.nlm.nih.gov/pubmed/30013179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0165-1
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