Tumor lineage shapes BRCA-mediated phenotypes

BRCA1 and BRCA2 mutations predispose to select cancers(1–3), and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients(4,5). These classical tumors suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, though hap...

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Pubblicato in:Nature
Autori principali: Jonsson, Philip, Bandlamudi, Chaitanya, Cheng, Michael L., Srinivasan, Preethi, Chavan, Shweta S., Friedman, Noah D., Rosen, Ezra Y., Richards, Allison L., Bouvier, Nancy, Selcuklu, S. Duygu, Bielski, Craig M., Abida, Wassim, Mandelker, Diana, Birsoy, Ozge, Zhang, Liying, Zehir, Ahmet, Donoghue, Mark T.A., Baselga, José, Offit, Kenneth, Scher, Howard I., O’Reilly, Eileen M., Stadler, Zsofia K., Schultz, Nikolaus, Socci, Nicholas D., Viale, Agnes, Ladanyi, Marc, Robson, Mark E., Hyman, David M., Berger, Michael F., Solit, David B., Taylor, Barry S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048239/
https://ncbi.nlm.nih.gov/pubmed/31292550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1382-1
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