Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability

Por Vacondio, Federica, Silva, Claudia, Lodola, Alessio, Carmi, Caterina, Rivara, Silvia, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Clapper, Jason R., Piomelli, Daniele, Tarzia, Giorgio, Mor, Marco
Publicado em 2011

Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain

Por Banappagari, Sashikanth, McCall, Alecia, Fontenot, Krystal, Vicente, M. Graca H., Gujar, Amit, Satyanarayanajois, Seetharama
Publicado em 2013

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Por Deng, Xianming, Elkins, Jonathan M., Zhang, Jinwei, Yang, Qingkai, Erazo, Tatiana, Gomez, Nestor, Choi, Hwan Geun, Wang, Jinhua, Dzamko, Nicolas, Lee, Jiing-Dwan, Sim, Taebo, Kim, NamDoo, Alessi, Dario R., Lizcano, Jose M., Knapp, Stefan, Gray, Nathanael S.
Publicado em 2013

Structure-function relationships of Nile blue (EtNBS) derivatives as antimicrobial photosensitizers

Por Vecchio, Daniela, Bhayana, Brijesh, Huang, Liyi, Carrasco, Elisa, Evans, Conor L, Hamblin, Michael R
Publicado em 2014

Novel 9′-substituted-noscapines: Synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation

Por Porcù, Elena, Sipos, Attila, Basso, Giuseppe, Hamel, Ernest, Bai, Ruoli, Stempfer, Verena, Udvardy, Antal, Bényei, Attila Cs., Schmidhammer, Helmut, Antus, Sàndor, Viola, Giampietro
Publicado em 2014

Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression

Por Penthala, Narsimha R., Bommagani, Shobanbabu, Janganati, Venumadhav, MacNicol, Kenzie B., Cragle, Chad E., Madadi, Nikhil R., Hardy, Linda L., MacNicol, Angus M., Crooks, Peter A.
Publicado em 2014

Structure-activity relationships of Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human Insulin-Degrading Enzyme

Por Charton, Julie, Gauriot, Marion, Totobenazara, Jane, Hennuyer, Nathalie, Dumont, Julie, Bosc, Damien, Marechal, Xavier, Elbakali, Jamal, Herledan, Adrien, Wen, Xiaoan, Ronco, Cyril, Gras-Masse, Helene, Heninot, Antoine, Pottiez, Virginie, Landry, Valerie, Staels, Bart, Liang, Wenguang G., Leroux, Florence, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca
Publicado no Eur J Med Chem (2014)

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2

Por Kaserer, Teresa, Temml, Veronika, Kutil, Zsofia, Vanek, Tomas, Landa, Premysl, Schuster, Daniela
Publicado no Eur J Med Chem (2015)

Discovery of HDAC Inhibitors with Potent Activity Against Multiple Malaria Parasite Life Cycle Stages

Por Hansen, Finn K., Sumanadasa, Subathdrage D. M., Stenzel, Katharina, Duffy, Sandra, Meister, Stephan, Marek, Linda, Schmetter, Rebekka, Kuna, Krystina, Hamacher, Alexandra, Mordmüller, Benjamin, Kassack, Matthias U., Winzeler, Elizabeth A., Avery, Vicky M., Andrews, Katherine T., Kurz, Thomas
Publicado no Eur J Med Chem (2014)

Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation

Por Romagnoli, Romeo, Baraldi, Pier Giovanni, Prencipe, Filippo, Lopez-Cara, Carlota, Rondanin, Riccardo, Simoni, Daniele, Hamel, Ernest, Grimaudo, Stefania, Pipitone, Rosaria Maria, Meli, Maria, Tolomeo, Manlio
Publicado no Eur J Med Chem (2015)

Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments

Por Jahan, Rajwana, Stephen, Michael Rajesh, Forkuo, Gloria S., Kodali, Revathi, Guthrie, Margaret L., Nieman, Amanda N., Yuan, Nina Y., Zahn, Nicolas M., Poe, Michael M., Li, Guanguan, Yu, Olivia B., Yocum, Gene T., Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Publicado no Eur J Med Chem (2016)

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

Por Agharbaoui, Fatima E., Hoyte, Ashley C., Ferro, Stefania, Gitto, Rosaria, Buemi, Maria Rosa, Fuchs, James R., Kvaratskhelia, Mamuka, De Luca, Laura
Publicado no Eur J Med Chem (2016)

Synthesis, stability and mechanistic studies of potent anticryptococcal hexapeptides

Por Shenmar, Kitika, Sharma, Krishna K., Wangoo, Nishima, Maurya, Indresh K., Kumar, Vinod, Khan, Shabana I., Jacob, Melissa R., Tikoo, Kulbhushan, Jain, Rahul
Publicado no Eur J Med Chem (2017)

Asymmetric 1,5-Diarylpenta-1,4-dien-3-ones: Antiproliferative Activity in Prostate Epithelial Cell Models and Pharmacokinetic Studies

Por Zhang, Xiaojie, Guo, Shanchun, Chen, Chengsheng, Perez, German Ruiz, Zhang, Changde, Patanapongpibul, Manee, Subrahmanyam, Nithya, Wang, Rubing, Keith, Joshua, Chen, Guanglin, Dong, Yan, Zhang, Qiang, Zhong, Qiu, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Publicado no Eur J Med Chem (2017)

The 4-N-Acyl and 4-N-Alkyl Gemcitabine Analogues with Silicon-Fluoride-Acceptor: Application to (18)F-Radiolabeling

Por Gonzalez, Cesar, Sanchez, Andersson, Collins, Jeffrey, Lisova, Ksenia, Lee, Jason T., van Dam, R. Michael, Barbieri, M. Alejandro, Ramachandran, Cheppail, Wnuk, Stanislaw F.
Publicado no Eur J Med Chem (2018)

Alkynyl-Containing Phenylthiazoles: Systemically Active Antibacterial Agents Effective Against Methicillin-resistant Staphylococcus aureus (MRSA)

Por Elsebaei, Mohamed M., Mohammad, Haroon, Abouf, Mohamed, Abutaleb, Nader S., Hegazy, Youssef A., Ghiaty, Adel, Chen, Lu, Zhang, Jianan, Malwal, Satish R., Oldfield, Eric, Seleem, Mohamed N., Mayhoub, Abdelrahman S.
Publicado no Eur J Med Chem (2018)

The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity

Por Negmeldin, Ahmed T., Knoff, Joseph R., Pflum, Mary Kay H.
Publicado no Eur J Med Chem (2017)

Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers

Por Fu, Dong-Jun, Song, Jian, Hou, Yu-Hui, Zhao, Ruo-Han, Li, Jia-Huan, Mao, Ruo-Wang, Yang, Jia-Jia, Li, Ping, Zi, Xiao-Lin, Li, Zhong-Hua, Zhang, Qing-Qing, Wang, Fei-Yan, Zhang, Sai-Yang, Zhang, Yan-Bing, Liu, Hong-Min
Publicado no Eur J Med Chem (2017)

Design, Synthesis, and Evaluation of Cystargolide-based β-lactones as Potent Proteasome Inhibitors

Por Niroula, Doleshwar, Hallada, Liam P, Le Chapelain, Camille, Ganegamage, Susantha K, Dotson, Devon, Rogelj, Snezna, Groll, Michael, Tello-Aburto, Rodolfo
Publicado no Eur J Med Chem (2018)

Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors

Por Zhou, Guangyan, Chu, Shidong, Nemati, Ariana, Huang, Chunsheng, Snyder, Beth A., Ptak, Roger G., Gochin, Miriam
Publicado no Eur J Med Chem (2018)