Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers

A series of 5,6-diaryl-1,2,4-triazines hybrids bearing a 1,2,3-triazole linker were synthesized by molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, EC-109 and PC-3). The first structure-activity relationship (SAR) for th...

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Publicado no:Eur J Med Chem
Main Authors: Fu, Dong-Jun, Song, Jian, Hou, Yu-Hui, Zhao, Ruo-Han, Li, Jia-Huan, Mao, Ruo-Wang, Yang, Jia-Jia, Li, Ping, Zi, Xiao-Lin, Li, Zhong-Hua, Zhang, Qing-Qing, Wang, Fei-Yan, Zhang, Sai-Yang, Zhang, Yan-Bing, Liu, Hong-Min
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975277/
https://ncbi.nlm.nih.gov/pubmed/28763643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.07.011
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