Molecular diversity of phenothiazines: design and synthesis of phenothiazine–dithiocarbamate hybrids as potential cell cycle blockers

Novel phenothiazine–dithiocarbamate analogues were designed by molecular hybridization strategy and synthesized and evaluated for their anticancer activity in vitro against three selected cancer cell lines (EC-109, MGC-803, and PC-3). The preliminary structure–activity relationship (SAR) for this ph...

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Veröffentlicht in:Mol Divers
Hauptverfasser: Fu, Dong-Jun, Zhao, Ruo-Han, Li, Jia-Huan, Yang, Jia-Jia, Mao, Ruo-Wang, Wu, Bo-Wen, Li, Ping, Zi, Xiao-Lin, Zhang, Qing-Qing, Cai, Hui-Jie, Zhang, Sai-Yang, Zhang, Yan-Bing, Liu, Hong-Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975273/
https://ncbi.nlm.nih.gov/pubmed/28785928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11030-017-9773-4
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