Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer

We designed a series of novel phenothiazine-1,2,3-triazole hybrids by the molecular hybridization strategy and evaluated their antiproliferative activity against three cancer cell lines (MDA-MB-231, MDA-MB-468 and MCF-7). For the structure-activity relationships, the importance of 1,2,3-triazole and...

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Huvudupphovsmän: Jun-Xia Zhang, Jiao-Mei Guo, Ting-Ting Zhang, Hong-Jun Lin, Nai-Song Qi, Zhen-Guo Li, Ji-Chun Zhou, Zhen-Zhong Zhang
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI AG 2018-05-01
Serie:Molecules
Ämnen:
phenothiazine-1,2,3-triazole
MCF-7
apoptosis
DR5
Länkar:http://www.mdpi.com/1420-3049/23/6/1288
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