Discovery of HDAC Inhibitors with Potent Activity Against Multiple Malaria Parasite Life Cycle Stages

In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235), previously shown to be a novel and specific inhibitor of human HDAC4 and 5, was used as a starting point to rapidly construct a...

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Publicado no:Eur J Med Chem
Main Authors: Hansen, Finn K., Sumanadasa, Subathdrage D. M., Stenzel, Katharina, Duffy, Sandra, Meister, Stephan, Marek, Linda, Schmetter, Rebekka, Kuna, Krystina, Hamacher, Alexandra, Mordmüller, Benjamin, Kassack, Matthias U., Winzeler, Elizabeth A., Avery, Vicky M., Andrews, Katherine T., Kurz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679366/
https://ncbi.nlm.nih.gov/pubmed/24904967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.05.050
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