Discovery of HDAC Inhibitors with Potent Activity Against Multiple Malaria Parasite Life Cycle Stages

In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235), previously shown to be a novel and specific inhibitor of human HDAC4 and 5, was used as a starting point to rapidly construct a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Eur J Med Chem
Autores principales: Hansen, Finn K., Sumanadasa, Subathdrage D. M., Stenzel, Katharina, Duffy, Sandra, Meister, Stephan, Marek, Linda, Schmetter, Rebekka, Kuna, Krystina, Hamacher, Alexandra, Mordmüller, Benjamin, Kassack, Matthias U., Winzeler, Elizabeth A., Avery, Vicky M., Andrews, Katherine T., Kurz, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679366/
https://ncbi.nlm.nih.gov/pubmed/24904967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.05.050
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares