Discovery of HDAC Inhibitors with Potent Activity Against Multiple Malaria Parasite Life Cycle Stages

In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235), previously shown to be a novel and specific inhibitor of human HDAC4 and 5, was used as a starting point to rapidly construct a...

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Bibliografski detalji
Izdano u:Eur J Med Chem
Glavni autori: Hansen, Finn K., Sumanadasa, Subathdrage D. M., Stenzel, Katharina, Duffy, Sandra, Meister, Stephan, Marek, Linda, Schmetter, Rebekka, Kuna, Krystina, Hamacher, Alexandra, Mordmüller, Benjamin, Kassack, Matthias U., Winzeler, Elizabeth A., Avery, Vicky M., Andrews, Katherine T., Kurz, Thomas
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679366/
https://ncbi.nlm.nih.gov/pubmed/24904967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.05.050
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