One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites

Malaria drug discovery has shifted from a focus on targeting asexual blood stage parasites, to the development of drugs that can also target exo-erythrocytic forms and/or gametocytes in order to prevent malaria and/or parasite transmission. In this work, we aimed to develop parasite- selective histo...

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Dades bibliogràfiques
Publicat a:Eur J Med Chem
Autors principals: Diedrich, Daniela, Stenzel, Katharina, Hesping, Eva, Antonova-Koch, Yevgeniya, Gebru, Tamirat, Duffy, Sandra, Fisher, Gillian, Schöler, Andrea, Meister, Stephan, Kurz, Thomas, Avery, VickyM., Winzeler, Elizabeth A., Held, Jana, Andrews, Katherine T., Hansen, Finn K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195125/
https://ncbi.nlm.nih.gov/pubmed/30245402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.018
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