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Macrocyclic Peptoid–Peptide Hybrids as Inhibitors of Class I Histone Deacetylases
[Image: see text] We report the design, synthesis, and biological evaluation of the first macrocyclic peptoid-containing histone deacetylase (HDAC) inhibitors. The compounds selectively inhibit human class I HDAC isoforms in vitro, with no inhibition of the tubulin deacetylase activity associated wi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4025818/ https://ncbi.nlm.nih.gov/pubmed/24900543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300162r |
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