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Design, Synthesis, and Evaluation of Cystargolide-based β-lactones as Potent Proteasome Inhibitors
The peptidic β-lactone proteasome inhibitors (PIs) cystargolides A and B were used to conduct structure-activity relationship (SAR) studies in order to assess their anticancer potential. A total of 24 different analogs were designed, synthesized and evaluated for proteasome inhibition, for cytotoxic...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168434/ https://ncbi.nlm.nih.gov/pubmed/30165344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.052 |
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