Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

The benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one core was discovered as a novel ERK5 (also known as MAPK7 and BMK1) inhibitor scaffold, previously. Further structure–activity relationship studies of this scaffold led to the discovery of ERK5-IN-1 (26) as the most selective and potent ERK5 inhibitor...

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Detalhes bibliográficos
Main Authors: Deng, Xianming, Elkins, Jonathan M., Zhang, Jinwei, Yang, Qingkai, Erazo, Tatiana, Gomez, Nestor, Choi, Hwan Geun, Wang, Jinhua, Dzamko, Nicolas, Lee, Jiing-Dwan, Sim, Taebo, Kim, NamDoo, Alessi, Dario R., Lizcano, Jose M., Knapp, Stefan, Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914206/
https://ncbi.nlm.nih.gov/pubmed/24239623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.10.052
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