ERK5 and Cell Proliferation: Nuclear Localization Is What Matters

Por Gomez, Nestor, Erazo, Tatiana, Lizcano, Jose M.
Publicado no Front Cell Dev Biol (2016)

SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation

Por Erazo, Tatiana, Espinosa-Gil, Sergio, Diéguez-Martínez, Nora, Gómez, Néstor, Lizcano, Jose M
Publicado no Int J Mol Sci (2020)

Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Comp...

Por Erazo, Tatiana, Moreno, Ana, Ruiz-Babot, Gerard, Rodríguez-Asiain, Arantza, Morrice, Nicholas A., Espadamala, Josep, Bayascas, Jose R., Gómez, Nestor, Lizcano, Jose M.
Publicado em 2013

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

Por Elkins, Jonathan M., Wang, Jing, Deng, Xianming, Pattison, Michael J., Arthur, J. Simon C., Erazo, Tatiana, Gomez, Nestor, Lizcano, Jose M., Gray, Nathanael S., Knapp, Stefan
Publicado em 2013

NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death

Por Liu, Yuxuan, Mondello, Patrizia, Erazo, Tatiana, Tannan, Neeta Bala, Asgari, Zahra, de Stanchina, Elisa, Nanjangud, Gouri, Seshan, Venkatraman E., Wang, Shenqiu, Wendel, Hans-Guido, Younes, Anas
Publicado no Proc Natl Acad Sci U S A (2018)

BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors

Por Derenzini, Enrico, Mondello, Patrizia, Erazo, Tatiana, Portelinha, Ana, Liu, Yuxuan, Scallion, Mary, Asgari, Zahra, Philip, John, Hilden, Patrick, Valli, Debora, Rossi, Alessandra, Djaballah, Hakim, Ouerfelli, Ouathek, de Stanchina, Elisa, Seshan, Venkatraman E., Hendrickson, Ronald C., Younes, Anas
Publicado no Cell Rep (2018)

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Por Deng, Xianming, Elkins, Jonathan M., Zhang, Jinwei, Yang, Qingkai, Erazo, Tatiana, Gomez, Nestor, Choi, Hwan Geun, Wang, Jinhua, Dzamko, Nicolas, Lee, Jiing-Dwan, Sim, Taebo, Kim, NamDoo, Alessi, Dario R., Lizcano, Jose M., Knapp, Stefan, Gray, Nathanael S.
Publicado em 2013

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis

Por París-Coderch, Laia, Soriano, Aroa, Jiménez, Carlos, Erazo, Tatiana, Muñoz-Guardiola, Pau, Masanas, Marc, Antonelli, Roberta, Boloix, Ariadna, Alfón, José, Pérez-Montoyo, Héctor, Yeste-Velasco, Marc, Domènech, Carles, Roma, Josep, Sánchez de Toledo, Josep, Moreno, Lucas, Lizcano, José M., Gallego, Soledad, Segura, Miguel F.
Publicado no Cell Death Dis (2020)

Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains

Por Wang, Jinhua, Erazo, Tatiana, Ferguson, Fleur M., Buckley, Dennis L., Gomez, Nestor, Muñoz-Guardiola, Pau, Diéguez-Martínez, Nora, Deng, Xianming, Hao, Mingfeng, Massefski, Walter, Fedorov, Oleg, Offei-Addo, Nana Kwaku, Park, Paul M., Dai, Lingling, DiBona, Amy, Becht, Kelly, Kim, Nam Doo, McKeown, Michael R., Roberts, Justin M., Zhang, Jinwei, Sim, Taebo, Alessi, Dario R., Bradner, James E., Lizcano, Jose M., Blacklow, Stephen C., Qi, Jun, Xu, Xiang, Gray, Nathanael S.
Publicado no ACS Chem Biol (2018)