X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

[Image: see text] The protein kinase ERK5 (MAPK7) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role mediating cell proliferation, survival, epithelial–mesenchymal transition, and angiogenesis. To date, no three-dimensional structure has been...

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Autors principals: Elkins, Jonathan M., Wang, Jing, Deng, Xianming, Pattison, Michael J., Arthur, J. Simon C., Erazo, Tatiana, Gomez, Nestor, Lizcano, Jose M., Gray, Nathanael S., Knapp, Stefan
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683888/
https://ncbi.nlm.nih.gov/pubmed/23656407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4000837
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